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In 30 patients the gold standardfor the diagnosis was histopathology from a biopsy; in 12 patients without biopsy, a follow-up of at least 6 months was available.
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Although themeasures of association using hazard ratios are reasonable (2.18 and 4.26), theDR and FPR are not satisfactory: either the DR is high (73%) but with high FPR(47%), or the DR is moderate (47%) but with lower FPR (22%). The main pathway results in the release of cell death factorsfrom mitochondria and the other minor pathway involves GrB activation of caspasesdownstream of mitochondrial involvement The main pathway results in the release of cell death factorsfrom mitochondria and the other minor pathway involves GrB activation of caspasesdownstream of mitochondrial involvement.
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