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For example, a large proportion of B6C3F1mice develop liver tumors before they die, and this sensi-tivity appears to be due in part to the fact that the H-rasoncogene in this mouse strain is hypomethylated, allowingthis oncogene to be expressed more easily, especially duringrecurrent hepatocellular injury.

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Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M, et al.Acarbose for prevention of type 2 diabetes mellitus: STOP-NIDDM randomizedtrial.

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fortunately, clinicians have several tools at theirdisposal that assist them in these tasks.